Genetic markers in glaucoma.
نویسندگان
چکیده
A number of genetic polymorphisms have been investigated in Negro and Caucasoid patients with glaucoma and the results compared with data obtained on healthy controls. A sample of 61 Negro patients was not significantly different from a sample of 238 controls with respect to 18 red cell and serum protein systems; no association between glaucoma and any of these systems could be demonstrated. The comparison among Caucasoids, using 14 systems, was made between 31 patients and 70 controls. The populations differed from each other in the rhesus and Duffy blood group systems, and a significant association between open-angle glaucoma and rhesus D (+) was found.
منابع مشابه
Glutathione s-transferase M1 and T1 genetic polymorphisms in Iranian patients with glaucoma
Objective(s):Glaucoma is the second leading cause of blindness and it is related to oxidative stress based on numerous studies. Glutathione S-transferases (GSTs) are members of multigenic family, which have important role in cells as an antioxidant. In the present study, we examined the polymorphism of GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0, and T0M0) in 100 Glaucoma patients (41with pr...
متن کاملThe Complex Disease Model of Glaucoma
S ince Pratap Challa, MD, wrote about genetics and glaucoma for Glaucoma Today in 2003,1 investigators have expanded previously successful research to identify more genes associated with this potentially blinding disease. This article updates the ongoing search for genetic markers for glaucoma and genes that contribute to the disease’s onset and progression, discusses the shift from a singlegen...
متن کاملBlood groups as genetic markers in glaucoma.
A series of 474 mixed cases of glaucoma was assessed to determine whether there were any genetic differences between different types of glaucoma. A careful distinction was made between chronic open angle glaucoma (COAG), acute and chronic angle closure glaucoma, ocular hypertension, low tension glaucoma, patients with large cup disc ratios, and various types of secondary glaucoma including pseu...
متن کاملAssociation between IL-6 genetic polymorphisms and primary open-angle glaucoma risk in Chinese population
Primary open angle glaucoma (POAG) is a one of the most common eye diseases in the world, especially in China. Many inflammatory markers are likely to be closely related to the development of POAG, especially cytokines. The aim of our investigation is to reveal the potential association of three interleukin-6 (IL-6) gene SNPs on primary open-angle glaucoma risk factors in Chinese. A case-contro...
متن کاملEvaluation and Comparison of the Efficiency of Different Molecular Markers in Estimating Genetic Distance of Different Persian Oak (Quercus brantii Lindi.) Populations in Lorestan Province, Iran
Estimation of genetic diversity and evaluation of plant germplasm is the most important step in collection and management of plant genetic resources. Also, comparison of different DNA-based genetic markers in diversity evaluation and then advising the most efficient markers is very important. In order to investigate genetic variation among Persian oak (Quercus brantii Lindi.) populations of Lor...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The British journal of ophthalmology
دوره 64 4 شماره
صفحات -
تاریخ انتشار 1980